Fatty acids and aortic valve stenosis

Aortic valve stenosis (AVS), a valvulopathy that threatens life quality and longevity, in particular an aging population. Yet no medical treatment is to date available emphasizing the need for more mechanistic insight into disease provide future targets. Obesity genetic variants within genes involved lipid metabolisms lipoprotein (a) have emerged as risk factors AVS these significant genome-wide associations. The metamorphosis of aortic severe calcification involves infiltration, inflammation, oxidative stress which promotes further viscous cycle tandem with biomechanical trigger recruitment inflammatory cells. resolution inflammation active regulated process therefore offers new possible Fatty acids serve substrate many mediators may counterbalance by promoting macrophage-mediated healing leading dampened response. Recent data put fatty spotlight important mechanism development disease. This review discusses mechanisms exerted context facilitate search therapeutic